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KMID : 0869619990160020225
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Journal of Korean Society of Hospital Pharmacists
1999 Volume.16 No. 2 p.225 ~ p.228
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The Decrease in Potency of Digestion of Starch by the Change of Formulation in Digestants
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양유리/Yang, You Ri
윤성미/김재연/노환성/Youn, Sung Mi/Kim, Jae Youn/Ro, Hwan Seong
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Abstract
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Digestants are made of enteric coated, multistage, or complex-form tablet for protecting against gastric deactivation and allowing delivery of predictable, high levels of biologically active enzyme to the target site for example stomach, duodenum. So when they are crushed, the stability of digestants are decreased evidently. The purpose of this study is to evaluate how much degree does the digestive action decrease especially in starch, when the formulation is changed to powder. The results are follows. Basic digestive potency per gram is little difference between capsules and tablets (3.16±0.09 (IU/g), 3.21±0.12 (IU/g) (P=0.3777, CI=95%) but capsules are more potent in digestion than tablet when they are pretreated by pH 1.2 gastric acids (0.48±0.13, 0.72±0.11, P=0.0055, CI=95%). The rate of decrease indigestive action is higher in tablet than in capsule (84±3.59%, 77.5±2.99% (P=0.0036, CI=95%). There, We made a determination that change of formulation made a greate decrease in digestive action especially enteric coated tablets.
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